Bulsiewicz reads inflammation as the thread running through dozens of complaints that seem to have nothing in common.
He starts from his clinic, where people who came in for constipation or IBS often also mentioned allergies, low mood or thyroid trouble. His case is that a strained gut keeps the immune system on alert, and that this low, steady inflammation feeds many conditions at once. Chronic inflammation is linked to many diseases in research, but how much it drives each one is still debated, so treat this as the author's framing.